AFP and neoplasm: This may be related to many confounding factors: first, performance status after LT is an important issue, which depends on the complication of operation, side effects of immunosuppressants, and risk of opportunistic infections; second, previous studies have demonstrated that the period early after LT is associated with poor prognosis, indicating that a shorter recurrence time may reduce the effect of sorafenib; other prognostic variables were reported, such as the tumor location, serum alpha-fetoprotein (AFP) level, sites of distant metastasis, and number of organ involvement [8,20,21].