While BRCA1/2 germline variants in BRCA, OV, PAAD and prostate cancer are well known to be associated with HRD phenotype, our results identify a much broader range of cancers with different germline alterations in HR-related genes that are significantly associated with HRD (Table 1 and Table S3). The gene discussed is BRCA1; the disease is pancreatic adenocarcinoma.