Cases with at least one somatic copy-number deletion in any of the HR genes (excluding BRCA1/2) showed significantly higher HRD scores compare to cases without deletions in OV, BRCA, Sarcoma (SARC), TGCT, adrenocortical carcinoma (ACC), low grade glioma (LGG), and UCEC (FDR < 0.05) (Figure 4B). This evidence concerns the gene BRCA1 and central nervous system cancer.