ACSL4 and neoplasm: Other authors confirmed that ionizing radiation induced ferroptosis in cancer cells through ROS formation and by affecting ACSL4 expression, a lipid metabolism enzyme required for such process; such action resulted in increased lipid peroxidation and ferroptosis and they demonstrated that ACSL4 ablation abolished the ferroptosis and promoted radioresistance; ferroptosis, a form of regulated cell death caused by lipid peroxidation, has been recently identified as a natural tumor suppression mechanism even in cancer cells [87].