It has been reported a wide connection with the hallmarks of cancer and RIBE; inducing angiogenesis (HIF-1, JAK-STAT/Akt), resisting cell death (autophagy, cAMP, rescue effect), inducing proliferative signaling (TGF-b, PCNA, CDC2), evading growth suppressors (CDKN1A, TP53), avoiding immune destruction (IL-6, CSF), deregulating cellular energetics (MtDNA, ROS, CYTc), inducing genomic instability (telomeres), promoting tumor inflammation (COX-2, TNFa, ROS), and inducing metastasis and invasion processes (AMPK/NFkb, JAK/STAT/Akt, VEGF/MMP2) [52]. The gene discussed is AKT1; the disease is neoplasm.