In the present study, chloroquine was not assessed for its effects on nuclear translocation of TFEB; however, it should be noted that lysosomotropic agents can increase translocation of TFEB; this results in increased lysosomal biogenesis and cancer resistance [37,38], which perhaps indicates that chloroquine is not the best option for treating patients with CLL. The gene discussed is TFEB; the disease is B-cell chronic lymphocytic leukemia.