AGT and glioblastoma: It is interesting to observe how estradiol produced by both tested glioblastoma cell lines in the presence of an aromatizable steroid such as androstenedione was significantly increased by the combined exposure to both Ang II and androstenedione, confirming again the intrinsic properties of Ang II/AGTR1 signaling to stimulate the intracellular aromatase enzymatic activity (Figure 8A).