CDH2 and glioblastoma: Indeed, estradiol not only stimulates glioblastoma cell proliferation well-fitting with our present data [47] but also induces a change in cell morphology displaying an elongated cell phenotype correlated with actin filaments rearrangements, together with an increase of cell migration, invasion, and upregulation of EMT markers such as Vimentin and N-Cadherin in GBM cell lines [47,48,49,50].