The molecular background of all the described events is the LOS inhibitory interference with transforming growth factor-beta 1 (TGF-β1) signaling taking part in different cellular signaling pathways affecting tumor stroma as well as cellular behavior, including migration, proliferation, differentiation, apoptosis, and particularly epithelial–mesenchymal transition (EMT) in glioblastoma [38,39,40,41,42,43,44]. Here, TGFB1 is linked to neoplasm.