MT2A and esophageal squamous cell carcinoma: To explore the functional role of MT2A in the ESCC cell lines, we silenced MT2A in TE-10 and TE-11 using siRNA (TE-10 and TE-11 siMT2A; Figure 5C,D and Figure S8G), and found remarkable changes in the cell morphology; the cells displayed a rounder shape and had proliferated more densely (Figure 5E).