Our cDNA microarray analysis suggested that plasminogen activator inhibitor-1 (PAI-1) promoted the CAF-like cell-induced migration and invasion by ESCC cells and macrophages through the activation of Akt and Erk signaling via LDL receptor-related protein 1 (LRP1) [17]. This evidence concerns the gene LRP1 and esophageal squamous cell carcinoma.