High expression of MT2A in the cancer stroma was significantly associated with the depth of tumor invasion (p = 0.001), lymphatic vessel invasion (p < 0.001), blood vessel invasion (p = 0.008), lymph node metastasis (p = 0.031), pathological stage (p = 0.031), expression of alpha-smooth muscle actin (αSMA; p < 0.001) and FAP (p < 0.001), and infiltrating numbers of CD163+ (p = 0.004) and CD204+ (p < 0.001) cells. The gene discussed is ACTA1; the disease is cancer.