While Zhao et al. demonstrated that the direct interaction of MT2A with the BRCA1-associated RING domain 1 (BARD1) and MT2A-BARD1/BRCA1 axis promoted oxaliplatin resistance in colorectal cancer cells [27], another study reported that MT2A knockdown led to a high rate of apoptosis induced by cisplatin treatment in malignant pleural mesothelioma [28]. This evidence concerns the gene BRCA1 and colorectal cancer.