CD8A and neoplasm: Previously, we demonstrated the tumor endothelial FasL was induced by tumor-derived VEGF, IL-10, and prostaglandin 2 (PGE2) and the combined use of anti-VEGF antibody and acetylsalicylic acid helped to attenuate FasL expression through inhibiting VEGF and PGE2; these interventions substantially increased infiltration of CD8+ TILs [156].