Its specific silencing leads to the downregulation of proto-oncogenes (e.g., β-catenin, Myc, and STAT) and epithelial-to-mesenchymal (EMT) markers, and reduces the dye-efflux potential and the aldehyde dehydrogenase 1 (ALDH1) activity of HCC cells. Here, MYC is linked to hepatocellular carcinoma.