In particular, Callegari et al. demonstrated the effectiveness of miR-199a-3p mimics in reducing tumor growth in the miR-221 TG mouse model, and confirmed the regulation of its well-known target genes, mTOR and p21 activated kinase 4 (PAK4), as one of the main molecular mechanisms responsible for its antitumor activity. This evidence concerns the gene PAK4 and neoplasm.