The COLVERA® (Clinical Genomics, Bridgewater, NJ, USA) assay is a 2-gene (BCAT1/IKZF1) methylation-specific, plasma ctDNA platform that is also commercially available and has shown greater sensitivity for recurrence in resected, localized CRC than CEA [28,40,41,42,43]. Here, CEACAM5 is linked to colorectal carcinoma.