Interestingly, they also found that the pooled incidence of pseudo-progression was higher in melanoma patients treated with CTLA-4 inhibitor (9.7%) compared to studies of PD-1/PD-L1 inhibitor monotherapy (5.7%; 95% CI: 4.8%, 6.6%); in particular, in studies of NSLSC patients treated with PD-1 inhibitor, the incidence of pseudo-progression ranged from 3.4% to 6.9%. The gene discussed is PDCD1; the disease is melanoma.