Interestingly, Rühle et al. found that patients with no hypoxia resolution between weeks 0 and 2, and PD-L1 expression on tumor cells (TPS of at least 1%) showed significantly worse locoregional control (LRC; HR = 3.374, p = 0.022) and a trend towards reduced PFS (HR = 2.752, p = 0.052), while the PD-L1 expression of the tumor cells did not influence the outcomes of patients with early tumor hypoxia resolution. The gene discussed is CD274; the disease is neoplasm.