While several studies have demonstrated how imaging phenotypes are connected to somatic mutations through an integrated analysis of NSCLC patients with somatic mutation testing and [18F]FDG PET/CT images using both radiomic and AI, only one study by Jiang at al. [174] explored the potential value of radiomic features from [18F]FDG PET/CT images in assessing different PD-L1 mutational status in 399 NSCLC. The gene discussed is CD274; the disease is non-small cell lung carcinoma.