INSIG1 and breast cancer: A study focused on the characterization of specific dysregulations in lipid metabolism conducted by Hilvo et al. reported increased levels of phospholipids, sphingomyelins, and ceramides, and the overexpression of four enzymes involved in de novo lipid metabolism (acetyl-CoA carboxylase alpha (ACACA), fatty acid synthase (FASN), insulin-induced gene 1 (INSIG1), and sterol regulatory element-binding transcription factor 1 (SREBP1)) in BC compared to healthy tissues [60].