In this study, basal-like BC models displayed higher concentrations of glycerophosphocholine (GPC) than PCho and higher glycine concentrations, which could be explained by lower choline kinase (CHKA, CHKB) expression and higher PtdCho degradation mediated by the overexpression of phospholipase A2 group 4A (PLA2G4A) and phospholipase B1 (PLB1). This evidence concerns the gene CHKA and breast cancer.