ADA and neoplasm: Related studies suggested the overexpression of ecto-5’-nucleotidase (CD73, which catalyzes the dephosphorylation of adenosine monophosphates into adenosine) in BC cells and an associated modulation of tumor growth and metastasis [80,81]; meanwhile, the observed increased activity of adenosine deaminase (ADA) in BC tumors [82,83,84] may represent a diagnostic tool for BC [83,84].