Indeed, it has been reported in HNSCC that adenosine produced by TEX-bound CD73/CD39 promote the A2BR-mediated polarization of macrophages toward a pro-tumoral M2-like phenotype, which leads to an increase in production of IL-10, Arg-1, and angiogenesis factors (angiopoietin-1, endothelin-1, IL-8 and platelet factor 4) [78]. The gene discussed is ENTPD1; the disease is head and neck squamous cell carcinoma.