In colorectal liver metastasis, single-cell analyses defined two mutually exclusive subsets of tumor cells with divergent response to chemotherapy: the stem-like cells (tumors cells which mainly use the PD-1/PD-L1 pathway to control immunity) and the enterocyte-like cells (which use the Tim-3/galectin-9 pathway to evade immunity) [337]. This evidence concerns the gene LGALS9 and neoplasm.