Motivated by the above insights, in earlier work [19], we showed that CD36 in normal primary mammary FBs is downregulated as a result of exposure to activin A; and overexpression of CD36 in FBs in cocultures with 3D colonies, either inhibits colony growth or reverses aberrant basal and lateral polarities, as a function of the breast cancer subtypes. Here, CD36 is linked to breast cancer.