In contrast, T cells recognizing hematopoiesis-restricted MiHA peptides, i.e., only expressed in cells of hematopoietic origin, such as HA-1 and HA-2, can lead to complete remissions in leukemia patients that relapsed after receiving allo-HSCT by inducing GVL without severe GVHD [47]. This evidence concerns the gene XIAP and leukemia.