The Tribbles Research and Innovation Network (TRAIN) was developed in the context of the medical need to understand the contribution that Tribbles (TRIB) proteins make in regulating processes governing the physiological functioning of macrophages and other immune cells, adipocytes and prostate epithelial cells in immuno-metabolic disease (such as obesity) and several cancers. This evidence concerns the gene RIBC2 and obesity due to melanocortin 4 receptor deficiency.