Here, we acknowledge some of the TRIB-research and people that have made it so and refer readers to some excellent review articles [2,3,4,5,6] that are interesting but tangential to the central theme of this commentary: why dissecting the cell-specific functions of TRIB isoforms could help cut through the biological complexities of obesity-related cancers. Here, RIBC2 is linked to obesity due to melanocortin 4 receptor deficiency.