Of the total CD4+ T-LGL leukemia cases, in 48 of them, Vβ usage was described in detail, and there was no Vβ skewing in most cases (n = 20; 41.7%) or Vβ13.1 expansion (n = 16; 33.3%). The gene discussed is CD4; the disease is T-cell large granular lymphocyte leukemia.