A number of murine pancreatitis models, centered around the use of cerulein, suggest that NF-κB activation in the pancreas is damaging [102,111,126], due to constitutive acinar cell canonical NF-κB activation targeting IKK2 (IKKβ) [127] or nuclear translocation of p65/RelA [43,128]. This evidence concerns the gene IKBKB and pancreatitis.