In lung cancer, PRI-219, a vitamin D3 active metabolite (24R-1,24-dihdroxycholecalciferol), in combination with a hydroxystilbene, RSV (3,5,4′-trihydroxystilbene), induced a significant increase in PD-L1 mRNA expression in NCIH358, A549, and HCC827 cells when compared to PRI-2191 treatment alone [50]. The gene discussed is CD274; the disease is lung cancer.