Lung disease in CF is characterized by neutrophil-dominated airway inflammation with excessive concentrations of proteases (e.g., neutrophil elastase) and proinflammatory cytokines (i.e., tumor necrosis factor [TNF], interleukin (IL)-1, IL-6, and IL-8), which are associated with lung disease progression and shortened survival [3]. The gene discussed is ELANE; the disease is lung disorder.