Although bacterial vaginosis, which is caused by an imbalance in the vaginal flora and an overgrowth of Gardnerella, is not recognized as a BSTI, one of the recent reports showed that the genus-specific effect of the PM-477 endolysin was shown not only in suspension but also ex vivo on biofilms of Gardnerella on exfoliated vaginal epithelial cells obtained from patients with bacterial vaginosis [131]. Here, PRB1 is linked to bacterial vaginosis.