Analyses employing the miRPathDB Reactome database confirmed that the CNS DLBCL-specific miR set is significantly linked to the following pathways: PIP3 activated AKT signaling, TGF-beta receptor complex, and transcriptional regulation by TP53 pathways, as well as PTEN regulation, interleukin-4 and interleukin-13 signaling, signaling by nuclear receptors, and TP53 regulates metabolic genes (Table S15). The gene discussed is PTEN; the disease is diffuse large B-cell lymphoma.