We also found that those 205 CNS DLBCL-specific miRs participate in the regulation of a number of signaling pathways, including FoxO, HIF-1, PI3K-Akt, TGF-beta, mTOR, ErbB, and TP53 (miRPathDB KEGG database) (Table S15). Here, AKT1 is linked to diffuse large B-cell lymphoma.