The discovery that 14-3-3 proteins are involved in the mechanism of stimulation of the H+-ATPase, being their association to the proton pump strongly stabilized by the toxin, opened new perspectives since 14-3-3 are a class of regulatory proteins ubiquitary in eukaryotes where they regulate fundamental cellular processes whose degeneration often underlies cancer or neurodegenerative disorders. This evidence concerns the gene YWHAQ and cancer.