Indeed, in a rat model of PAH (SU5416 plus hypoxia) occurring through vascular endothelial growth factor receptor 2 (VEGFR2) inhibition, elevated production of mitochondrial-derived ROS induces a Ca2+ influx via TRPV4, which promotes enhanced migratory and proliferative responses in PAEC [120]. This evidence concerns the gene KDR and pulmonary arterial hypertension.