In a pre-clinical study using a CH-induced PH murine model, Sun et al. demonstrated that intratracheal TRPC1 siRNA delivery reduces the production of pro-fibrosis factors, increases endothelial nitric oxide synthase (eNOS) expression that favors vasodilatation, and decreases pro-apoptotic factors, overall attenuating PH phenotype [79]. Here, NOS3 is linked to cyclic hematopoiesis.