TRPC1 and cyclic hematopoiesis: Indeed, in CH or MCT rat models, chrysin, a component of medicinal plants, inhibits PH-induced TRPC1/6 upregulation, modulates Ca2+ homeostasis, reduces PASMC proliferation, and reactive oxygen species production, attenuating the PH phenotype (right ventricular pressure and hypertrophy, and vascular remodeling) [95,96].