Indeed, in CH trpv4−/− mice, all the features of PH are reduced, such as right ventricle heart hypertrophy, remodeling via muscularization of the arteries [23], PA pressure increase associated with hypoxic pulmonary vasoconstriction [122], and enhancement in 5-HT induced contraction [116]. The gene discussed is TRPV4; the disease is cyclic hematopoiesis.