AR and Familial prostate cancer: Since AR signaling is the most critical factor in prostate cancer development and progression, we examined the effect of androgen stimulation on the expression of PAQR genes using the NCBI GEO dataset GDS2782, which was generated in LNCaP cells after dihydrotestosterone (DHT) stimulation plus Bicalutamide blockage for 16 h using the cDNA microarray approach [20].