In addition to glucose metabolism with PYGB, a KD gene overlapping BC and CRP/IL6, the BC pathways included immune regulatory interactions/chemokine receptor mechanisms/JAK-STAT signaling with their KDs (CD3D, CD3G, IL2, IL4, JAK1/2/3, STAT6, and TYK2), all of which overlapped key regulatory genes in the CRP/IL6-assocaited gene networks. Here, PYGB is linked to breast cancer.