ERBB4 and breast cancer: Moreover, we detected ERBB4 signaling as one of the topmost significant pathways shared by CRP/IL6 and BC development; this finding is supported by previous studies reporting that (a) human pro-inflammatory macrophages stimulating CRP/IL6 production induces ERBB4 expression and (b) CRP/IL6 correlates with breast tissue aromatase levels in women diagnosed with BC and those with a high risk of BC [61].