Univariate and multivariate regression analysis for SLE patients with and without nephritis revealed that the MECP2 rs2734647 genotypes CT and TT are independent predictors of nephritis in SLE patients, with (OR 2.70, p = 0.016) and (OR 2.648, p = 0.034), respectively. Here, MECP2 is linked to systemic lupus erythematosus.