Following adjustment for age, SBP, DBP, and arthralgia and arthritis patterns, univariate, and multivariate regression analysis of all SLE patients relative to controls revealed that the MECP2 rs2734647 genotypes CT and TT could be independent predictor of disease, with (OR 2.951, p = 0.001) and (OR 4.343, p = 0.015), respectively. The gene discussed is MECP2; the disease is Arthralgia.