The presence of the T allele of MECP2 rs2734647 increases susceptibility to the disease where the individual CT and TT genotypes increase the risk of SLE with an odds ratio (OR) of 2.648 (p = 0.005) and 4.569 (p = 0.024), respectively, while having both (CT and TT) increased the risk with an OR of 2.951 (p = 0.001). The gene discussed is MECP2; the disease is systemic lupus erythematosus.