TIRAP and systemic lupus erythematosus: Moreover, we noticed that the CT and TT genotypes of TIRAP rs8177374 increased the risk of SLE with an OR of 3.283 (p < 0.001) and 3.203 (p = 0.172), respectively, while having both (CT and TT) increased the risk with an OR of 3.274 (p < 0.001).