TIRAP rs8177374 (C/T) SNP, which causes a leucine substitution at serine 180 of Mal (S180L), is associated with an increase in susceptibility to infectious diseases such as malaria, tuberculosis, and septic shock; moreover, S180L leads to an amino acid substitution in which Mal alters TLR2 and TLR4 signaling; hence, it could protect against life-threatening inflammatory disorders [7]. The gene discussed is TIRAP; the disease is tuberculosis.