TLR2 and lobular neoplasia: Cyclophosphamide is an alkylating agent that is used in severe cases of LN to suppress the immune system by diminishing the overproduction and infiltration of neutrophils [47], as well as downregulation of TLR2, which activates cytokines such as IL-10 by differentiating the Treg cells (TLR2-expressing dependent cell), which are the most important sources of IL-10 [48].