TGFB1 and myocardial infarction: Accordingly, inhibition of TGFβ signaling in mice by intraperitoneal injection of an antibody that specifically neutralizes TGFβ1–3, 7 d before or 5 d after MI (non-reperfused) results in reduced type I collagen mRNA expression in the infarcted region in the early phase of MI, worsened left ventricular remodeling and increased mortality [106].