Several CNS pathophysiological conditions were examined by Liddelow et al. and revealed that GFAP/C3-positive astrocytes were present in PD patients’ SN, AD prefrontal cortex and hippocampus, amyotrophic lateral sclerosis (ALS) motor cortex, Huntington’s disease (HD) caudate nucleus, and multiple sclerosis (MS) subcortical tissue [71]. Here, GFAP is linked to Huntington disease.