In conclusion, our data show that TNF-α stimulation induces the IP-10 transcripts/protein expression in MCF-7 breast cancer cells through the mechanism involving JNK/c-Jun-mediated signaling, which implies that targeting the JNK/c-Jun kinases of MAPK pathway may have significance in alleviating TNFα-/IP10-mediated breast cancer progression and metastasis. The gene discussed is MAPK8; the disease is breast cancer.