Of note, Mulligan et al. assessed expression of IP-10/ CXCL-10 and its receptor CXCR3 in 364 breast carcinomas using tissue microarrays and showed that IP-10 could play a role in lymphocytic infiltrate migration and invasion, suggesting that IP-10 acted in a paracrine manner to affect the tumor microenvironment as well as in an autocrine manner to act on the tumor cells themselves and thus played a role in tumor progression and invasiveness. The gene discussed is CXCR3; the disease is neoplasm.