One of the disorders connected to PCOS is low-grade inflammation, itself directly implicated in systemic endothelial dysfunction; low-grade inflammation was shown to be significantly reduced when PCOS patients were treated with metformin, an insulin-sensitizing drug, thus suggesting that insulin resistance is one of the biomediators of low-grade inflammation in PCOS [33]. The gene discussed is INS; the disease is polycystic ovary syndrome.