In our recent study, we generate the mice with a targeted deletion of H1R in different types of neurons, including glutamatergic neurons (CaMKIIα-Cre;Hrh1fl/fl), dopaminergic neurons (DAT-Cre;Hrh1fl/fl) or cholinergic neurons (ChAT-Cre;Hrh1fl/fl) by using the Cre-LoxP system and find that ChAT-Cre;Hrh1fl/fl mice, instead of CaMKIIα-Cre;Hrh1fl/fl or DAT-Cre;Hrh1fl/fl mice, exhibit the behavioral deficits related to negative symptoms of schizophrenia. This evidence concerns the gene CAMK2A and schizophrenia.