The authors showed that in PTEN-null triple-negative breast cancer, when the phosphomimetic S72E mutant of Rab7A is overexpressed, hence when Rab7A cannot be activated, the degradation of STING is suppressed, and the production of cytokines, such as CCL5, CXCL10 and IFNβ, is aberrantly enhanced. This evidence concerns the gene RAB7A and triple-negative breast carcinoma.