The tyrosol derivatives (-)-oleocanthal in extra virgin olive oil are recognized to act in more than one way in the modulation of the phenotype plasticity of mammary cancer cells: (i) suppressing the expression of the mesenchymal marker vimentin; (ii) restoring the expression of E-cadherin and Zo-1 in MDA-MB-231 cancer cells; (iii) stabilizing the expression of E-cadherin and Zo-1 in MCF-7 and BT-474 breast cancer cells; (iv) blocking the HGF/c-Met activation in MDA-MB-231, MCF-7, and BT474 cancer cell lines in culture [70,71]. This evidence concerns the gene CDH1 and breast cancer.