As concerns bone colonization by prostate cancer, curcumin has demonstrated multiple activities: it downregulates the expression of CXCR4, the receptor of the stromal chemokine CXCL12 expressed by osteoblasts and involved in the metastatic process [105]; it inhibits the serine/threonine kinase Akt activation and suppresses cell proliferation [106]. Here, CXCR4 is linked to Familial prostate cancer.