CXCR4 and prostate cancer: Resveratrol also prevents prostate cancer invasion and metastasis through several mechanisms: by reverting the EMT process, downregulating the androgen receptor and CXCR4 (CXCL12 chemokine receptor 4) pathway [64], by intervening in the bi-directional interplay between stromal and epithelial cells, and by inhibiting HGF-induced migratory behavior of prostate cancer cells [65].