The flavonoid apigenin (API),4′,5,7-trihydroxyflavone can suppress the oncogene Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan 1 (SPOCK1) expression normally upregulated in prostate cancer and responsible for the invasion and metastasis of cancer cells in a human prostate cancer xenograft model. Here, SPARC is linked to Familial prostate cancer.