LRRK2, a protein implicated in PD pathogenesis, and is also known to phosphorylate Rab5b and other 13 endogenous Rab proteins namely Rab3A/B/C/D, Rab5A/C, Rab8A/B, Rab10, Rab12, Rab29, Rab35, and Rab43 [69]. This evidence concerns the gene LRRK2 and Parkinson disease.