RAB3A and Lewy body dementia: Immunoblot and immunoprecipitation assays from patient brain samples suffering from Lewy-Body dementia, demonstrated that α-syn aggregates bind to Rab3a and disrupt Rab3a-rabphilin protein-protein interaction, resulting in an impairment of the docking of this complex to the synaptic vesicles transport (Figure 1B) [73].