In addition, it has been shown that a homozygous TRIM63/MuRF1 null mutation in combination with the heterozygous TRIM54/MuRF3 mutation leads to a myosin storage myopathy associated with skeletal muscle hypertrophy and hypertrophic cardiomyopathy in patients [391]. Here, TRIM54 is linked to hypertrophic cardiomyopathy.