In order to identify universal markers of atrophy, two genes encoding E3 ubiquitin ligases with restricted expression to striated muscles were found to be significantly upregulated in multiple early stage models of skeletal muscle atrophy: Muscle RING (really interesting new gene) finger 1 (MuRF1 encoded by Trim63) and atrogin-1/MAFbx [137,138,139,140,141]. This evidence concerns the gene TRIM63 and muscle atrophy.