Because other IL-6 cytokine family members such as IL-11, ciliary neurotrophic factor, leukemia inhibitory factor (LIF), oncostatin M, cardiotrophin 1, cardiotrophin-like cytokine and IL-27 also signal through gp130, they might as well play a role in sepsis-induced muscle wasting, but this needs to be proven [223]. The gene discussed is LIF; the disease is Sepsis.