CCNB1 and hepatocellular carcinoma: Recently, recombinant HsCaNB (rhCNB) has been implicated in the inhibition of the proliferation of gastric cancer cells and hepatomas, through the induction of apoptosis and arrest of the cell cycle, as rhCNB promotes the expression of p53 and decreases the expression of cyclin B1 and cyclin-dependent kinase 1 (Cdk1), contributing to arrest in G2/M [111].