CDK1 and colorectal carcinoma: Given that NNMT has previously noted to promote the cell cycle via the active G1 phase in CRC cells [6], and high expression of NNMT in both HT-29/NC and SW480/NNMT cells can protect CDK1, CDK2, cyclin A2, cyclin B1, and p-Rb against inhibition by Cur, which indicates that NNMT plays a role in promoting G2/M phase.