Collectedly, it is suggested that Cur could downregulate the endogenous expression of NNMT (in HT-29 cells) and p-STAT3 (in SW480 cells), but we cannot draw a conclusion that the inhibition of NNMT is due to the inhibition of p-STAT3 in CRC cells. The gene discussed is NNMT; the disease is colorectal carcinoma.