However, as NNMT is endogenously highly expressed and p-STAT3 is barely detected in HT-29 cells, in addition to NNMT being barely detected and p-STAT3 endogenously highly expressed in SW480 cells, we cannot conclude that the inhibition of NNMT by Cur is due to the inhibition of p-STAT3 in CRC cells, and we have not yet found a CRC cell line that possess high expression of both NNMT and p-STAT3. This evidence concerns the gene STAT3 and colorectal carcinoma.