In fibroblast-like synoviocytes the elevated expression of TLR2 can be regulated by miR-19a/b, what leads to decreased IL-6 production [66] and a decrease of TLR3 mRNA expression by miR-26a-5p in arthritic rats slowed the development of RA [67]. The gene discussed is TLR2; the disease is rheumatoid arthritis.