CpG-52364 (Coley Pharmaceutical) is also a TLR7/8/9 inhibitor, which works better than hydroxychloroquine sulfate in animal studies and it was tested in clinical trials for the oral treatment of SLE, although no results to the clinical study (NCT00547014; 2009) were posted [82]. The gene discussed is TLR7; the disease is systemic lupus erythematosus.