CXCL8 and Hypoglycemia: Along with the drive of the sympathoadrenal activation, several inflammatory markers including C-Reactive Protein (CRP), Interleukin 6 (IL-6), Interleukin 8 (IL-8), Tumor Necrosis Factor α (TNF-α), and endothelin-1, have been shown to be increased during hypoglycemia [45,46].