The best sensitivity and specificity for distinguishing the individual groups was achieved by the combination of other soluble biomarkers, such as 8-Hydroxy-2′-deoxyguanosine (8OHdG), vascular endothelial growth factor (VEGF), and soluble mesothelin-related peptides (SMRPs), indicating that they could have a better diagnostic value in mesothelioma [15,16]. This evidence concerns the gene VEGFA and mesothelioma.