As cells carrying the EGFR C797S mutation are associated with the higher expression of AXL [7] and quercetin was reported to inhibit the AXL-STAT3 pathway in glioblastoma cells [16], we hypothesized that quercetin-induced apoptosis and cytotoxicity may be highly related to the inhibition of AXL in H1975 and H1975-MS35 cells. This evidence concerns the gene EGFR and glioblastoma.