Remarkably, in support of the amyloid hypothesis, mutations causing inherited forms of AD lead to increased production of Aβ and the development of AD, while mutations in the Microtubule-Associated Protein (MAPT) gene encoding tau do not cause familiar AD, although they can lead to other neurodegenerative tauopathies which often include Parkinsonian symptoms [34]. The gene discussed is MAPT; the disease is Alzheimer disease.