MAPK8 and acute kidney injury: Similarly, Taraxacum officinale has a protective effect on H/R-induced AKI via inhibition of oxidative stress, inflammation, and apoptosis in the extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK) of the mitogen-activated protein kinase (MAPK) signaling pathways in vivo and in vitro [35].