A few overlapping targets have however been found in both APS-1 patients and autoimmunity prone mice: The orthologue to NALP5 (MATER) is an autoantigen for a murine model of autoimmune ovarian failure [99,100,101], and anti-BPIFB1 (bactericidal/permeability-increasing fold-containing B1) are present in both APS-1 and one of the AIRE-deficient mouse models [79,102]. Here, NLRP5 is linked to autoimmune polyendocrine syndrome type 1.