Autoantibody reactivity is commonly targeting the liver and pancreas, testis, lung, eye, and salivary gland, but no autoantibodies against the major autoantigens in APS-1, including amongst others 21OH, 17OH, SSC, AADC, and TPH, were found in mice lacking Aire [20,98]. This evidence concerns the gene AIRE and autoimmune polyendocrine syndrome type 1.