EPAS1 and cancer: Das et al. found that the related regulation of HIF2α, as a down-stream effector of Myc, can cause the cancer stem cells to undergo self-renewal or differentiation, in which the interaction among Myc, Sox2, and Nanog on the HIF2α promoter can modulate the level of p53, Glutathione (GSH) and reactive oxygen species (ROS) to determine cell fate [247].