EIF2AK3 and colonic neoplasm: Although the above reported study showed that DPE impaired cell survival in colon cancer cells carrying mutant (mut) and wild-type (wt) p53, most of the experiments were performed only in a mutp53 cell line, in which DPE activated the PERK/eIF2alpha/CHOP axis and the phosphatase PP2A, de-phosphorylating ERK1/2 and AKT [10].