The concentration of plasma cytokines of the TNF receptor superfamily (receptors—sTNF-R1, sTNFRSF8, and ligands—TNFSF12, TNFSF13, TNFSF13B) in obese patients with T2DM was lower than in patients without T2DM and the control group (p < 0.05) (Table 1). The gene discussed is TNFSF12; the disease is type 2 diabetes mellitus.