Zhang et al., 2021 reported that CD74 upregulation promotes the invasive ability of pancreatic ductal adenocarcinoma cells and modulates the expression of GDNF (glial cell-derived neurotrophic factor) via the AKT/EGR-1 pathway, enhancing perineural invasion [52]. The gene discussed is CD74; the disease is pancreatic ductal adenocarcinoma.