Moreover, an additional H3K9 HDM, Plant homeodomain finger protein 2 (Phf2), was shown to erase H3K9me2 methyl-marks on the promoter of carbohydrate-responsive element-binding protein, (ChREBP) thereby protects liver from the pathogenesis progression of NAFLD [127]. This evidence concerns the gene MLXIPL and metabolic dysfunction-associated steatotic liver disease.