TM6SF2 and metabolic dysfunction-associated steatotic liver disease: Among these, genetic variants in patatin-like phospholipase domain containing three protein (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), and membrane bound O-acyltransferase domain-containing seven gene (MBOAT7), which are involved in lipid droplets remodeling and very low-density lipoproteins secretion, are considered as the major determinants of interindividual differences in NAFLD trait [21,22].